Circulating giant macrophages as a potential biomarker of solid tumors. Proc Natl Acad Sci U S A 2014 Mar 04;111(9):3514-9
Date
02/20/2014Pubmed ID
24550495Pubmed Central ID
PMC3948254DOI
10.1073/pnas.1320198111Scopus ID
2-s2.0-84895802375 (requires institutional sign-in at Scopus site) 188 CitationsAbstract
Tumor-associated macrophages (TAMs) derived from primary tumors are believed to facilitate circulating tumor cell (CTC) seeding of distant metastases, but the mechanisms of these processes are poorly understood. Although many studies have focused on the migration of CTCs, less attention has been given to TAMs that, like CTCs, derive from tumor sites. Using precision microfilters under low-flow conditions, we isolated circulating cancer-associated macrophage-like cells (CAMLs) from the peripheral blood of patients with breast, pancreatic, or prostate cancer. CAMLs, which are not found in healthy individuals, were found to express epithelial, monocytic, and endothelial protein markers and were observed bound to CTCs in circulation. These data support the hypothesis that disseminated TAMs can be used as a biomarker of advanced disease and suggest that they have a participatory role in tumor cell migration.
Author List
Adams DL, Martin SS, Alpaugh RK, Charpentier M, Tsai S, Bergan RC, Ogden IM, Catalona W, Chumsri S, Tang CM, Cristofanilli MAuthor
Susan Tsai MD Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
BiomarkersBiopsy
Cell Movement
Cell Size
Filtration
Fluorescein-5-isothiocyanate
Giant Cells
Humans
In Situ Hybridization, Fluorescence
Kaplan-Meier Estimate
Macrophages
Microscopy
Neoplasms
Neoplastic Cells, Circulating
