Faculty Collaboration Database

Cerebral metabolites in patients with acute and subacute strokes: concentrations determined by quantitative proton MR spectroscopy. AJR Am J Roentgenol 1995 Sep;165(3):633-8

Date

09/01/1995

Pubmed ID

7645484

DOI

10.2214/ajr.165.3.7645484

Scopus ID

2-s2.0-0029093834 (requires institutional sign-in at Scopus site)   66 Citations

Abstract

OBJECTIVE: The purpose of this study was to determine the feasibility of measuring concentrations of cerebral metabolites in acute and subacute stroke patients using single-voxel localized proton MR spectroscopy and to compare these concentrations to those in contralateral brain regions and in normal healthy volunteers.

SUBJECTS AND METHODS: Single-voxel proton MR spectroscopy and MR imaging were performed in 14 stroke patients, at times ranging from 2 hr to 10 days following the onset of symptoms. Signals from choline, creatine, N-acetyl-L-aspartate (NAA), and lactate were quantified in the infarcted region (n = 14) and in the hemisphere contralateral to the stroke (n = 8) and compared with data obtained from a group of 10 control subjects.

RESULTS: Infarcts were characterized by significantly increased lactate (12 of 14 patients; 7.5 +/- 8.9 mumol/g wet weight, mean +/- SD) and significantly decreased NAA (12 of 14 patients; 5.5 +/- 3.2 mumol/g wet weight), compared with contralateral brain regions and control data in healthy volunteers. Significant reductions in choline, creatine, and NAA were also found in contralateral brain regions compared with the control patients.

CONCLUSION: Quantitative single-voxel proton spectroscopy is feasible for use in clinical studies of acute stroke. Ratio measurements or comparison with contralateral metabolites may be misleading because all metabolites may change during infarction, and contralateral metabolite levels may also be different from normal subjects.

Author List

Mathews VP, Barker PB, Blackband SJ, Chatham JC, Bryan RN

Author

Vincent Mathews MD Chair, Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acute Disease
Adolescent
Adult
Aged
Aged, 80 and over
Aspartic Acid
Brain
Cerebrovascular Disorders
Child
Choline
Creatine
Feasibility Studies
Female
Humans
Lactates
Lactic Acid
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Middle Aged