Faculty Collaboration Database

Cranial tissues: appearance at gadolinium-enhanced and nonenhanced MR imaging with magnetization transfer contrast. Radiology 1994 Feb;190(2):541-6

Date

02/01/1994

Pubmed ID

8284413

DOI

10.1148/radiology.190.2.8284413

Scopus ID

2-s2.0-0028157387 (requires institutional sign-in at Scopus site)   60 Citations

Abstract

PURPOSE: To determine the relative contrast of normal cranial tissues at magnetization transfer (MT) spin-echo magnetic resonance (MR) imaging.

MATERIALS AND METHODS: MR imaging at 1.5 T was performed with conventional spin-echo techniques without and with off-resonance MT saturation pulses. The signal intensities of normal cranial tissues were measured in 10 healthy volunteers on spin-density- and T2-weighted images and in 10 patients on T1- weighted images obtained before and after administration of gadopentetate dimeglumine.

RESULTS: MT saturation produced a significant (P < .01) reduction in signal from all tissues except cerebrospinal fluid and fat. Several gray matter structures had higher signal intensity than white matter on T1-weighted MT images. After administration of gadopentetate dimeglumine, imaging with the MT sequence increased visualization of normally enhancing structures.

CONCLUSION: MT saturation pulses produce new patterns of tissue contrast that differ substantially from those seen on conventional spin-echo images.

Author List

Elster AD, King JC, Mathews VP, Hamilton CA

Author

Vincent Mathews MD Chair, Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Brain
Cerebrospinal Fluid
Contrast Media
Drug Combinations
Female
Gadolinium DTPA
Humans
Magnetic Resonance Imaging
Male
Meglumine
Middle Aged
Organometallic Compounds
Pentetic Acid
Pituitary Gland
Scalp