Faculty Collaboration Database

AIDS-related CNS cryptococcosis: radiologic-pathologic correlation. AJNR Am J Neuroradiol 1992;13(5):1477-86

Date

09/01/1992

Pubmed ID

1414845

Pubmed Central ID

PMC8335225

Scopus ID

2-s2.0-0026702226 (requires institutional sign-in at Scopus site)   98 Citations

Abstract

PURPOSE: This study evaluates the effectiveness of cranial CT and MR in detecting autopsy findings of AIDS-related CNS cryptococcosis.

METHODS: Final imaging studies compared with pathology were CT in eight patients (five with contrast) and MR in five patients (all with Gd-DTPA).

RESULTS: Neither modality effectively identified cryptococcal meningitis. Punctate hyperintensities were seen in all patients with MR and corresponded pathologically to both perivascular spaces dilated by cryptococcal infection and cryptococcomas. Pathologically, cryptococcomas were more common than dilated perivascular spaces. MR detected more cryptococcomas than did CT, but both modalities underestimated the number of lesions seen at autopsy. Contrast enhancement of cryptococcomas and cryptococcal meningitis was uncommon.

CONCLUSIONS: CNS cryptococcosis was more effectively demonstrated by MR than by CT, but both modalities underestimated the pathologic extent of the disease. Cryptococcal lesion contrast enhancement was unusual possibly because of the immunocompromised state of our patients and the unique characteristics of the organism itself.

Author List

Mathews VP, Alo PL, Glass JD, Kumar AJ, McArthur JC

Author

Vincent Mathews MD Chair, Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acquired Immunodeficiency Syndrome
Adult
Brain
Cadaver
Central Nervous System Diseases
Cryptococcosis
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Tomography, X-Ray Computed