Faculty Collaboration Database

En face spectral domain optical coherence tomography analysis of lamellar macular holes. Retina 2014 Jul;34(7):1360-6

Date

03/29/2014

Pubmed ID

24667569

DOI

10.1097/IAE.0000000000000115

Scopus ID

2-s2.0-84903265982 (requires institutional sign-in at Scopus site)   22 Citations

Abstract

PURPOSE: To analyze the anatomical characteristics of lamellar macular holes using cross-sectional and en face spectral domain optical coherence tomography.

METHODS: Forty-two lamellar macular holes were retrospectively identified for analysis. The location, cross-sectional length, and area of lamellar holes were measured using B-scans and en face imaging. The presence of photoreceptor inner segment/outer segment disruption and the presence or absence of epiretinal membrane formation were recorded.

RESULTS: Forty-two lamellar macular holes were identified. Intraretinal splitting occurred within the outer plexiform layer in 97.6% of eyes. The area of intraretinal splitting in lamellar holes did not correlate with visual acuity. Eyes with inner segment/outer segment disruption had significantly worse mean logMAR visual acuity (0.363 ± 0.169; Snellen = 20/46) than in eyes without inner segment/outer segment disruption (0.203 ± 0.124; Snellen = 20/32) (analysis of variance, P = 0.004). Epiretinal membrane was present in 34 of 42 eyes (81.0%).

CONCLUSION: En face imaging allowed for consistent detection and quantification of intraretinal splitting within the outer plexiform layer in patients with lamellar macular holes, supporting the notion that an area of anatomical weakness exists within Henle's fiber layer, presumably at the synaptic connection of these fibers within the outer plexiform layer. However, the en face area of intraretinal splitting did not correlate with visual acuity, disruption of the inner segment/outer segment junction was associated with significantly worse visual acuity in patients with lamellar macular holes.

Author List

Clamp MF, Wilkes G, Leis LS, McDonald HR, Johnson RN, Jumper JM, Fu AD, Cunningham ET Jr, Stewart PJ, Haug SJ, Lujan BJ

Author

Geoffrey Owen Wilkes MD Assistant Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Retina
Retinal Perforations
Retrospective Studies
Tomography, Optical Coherence
Visual Acuity