Enhanced survival from radiation pneumonitis by combined irradiation to the skin. Int J Radiat Biol 2014 Sep;90(9):753-61
Date
05/16/2014Pubmed ID
24827855Pubmed Central ID
PMC4380176DOI
10.3109/09553002.2014.922722Scopus ID
2-s2.0-84907045554 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
PURPOSE: To develop mitigators for combined irradiation to the lung and skin.
METHODS: Rats were treated with X-rays as follows: (1) 12.5 or 13 Gy whole thorax irradiation (WTI); (2) 30 Gy soft X-rays to 10% area of the skin only; (3) 12.5 or 13 Gy WTI + 30 Gy skin irradiation after 3 hours; (4) 12.5 Gy WTI + skin irradiation and treated with captopril (160 mg/m(2)/day) started after 7 days. Our end points were survival (primary) based on IACUC euthanization criteria and secondary measurements of breathing intervals and skin injury. Lung collagen at 210 days was measured in rats surviving 13 Gy WTI.
RESULTS: After 12.5 Gy WTI with or without skin irradiation, one rat (12.5 Gy WTI) was euthanized. Survival was less than 10% in rats receiving 13 Gy WTI, but was enhanced when combined with skin irradiation (p < 0.0001). Collagen content was increased at 210 days after 13 Gy WTI vs. 13 Gy WTI + 30 Gy skin irradiation (p < 0.05). Captopril improved radiation-dermatitis after 12.5 Gy WTI + 30 Gy skin irradiation (p = 0.008).
CONCLUSIONS: Radiation to the skin given 3 h after WTI mitigated morbidity during pneumonitis in rats. Captopril enhanced the rate of healing of radiation-dermatitis after combined irradiations to the thorax and skin.
Author List
Gao F, Fish BL, Szabo A, Schock A, Narayanan J, Jacobs ER, Moulder JE, Lazarova Z, Medhora MAuthor
Aniko Szabo PhD Professor in the Data Science Institute department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCaptopril
Collagen
Female
Fibrosis
Lung
Radiation Injuries
Radiation Injuries, Experimental
Radiation Pneumonitis
Rats
Skin
Thorax
Time Factors
Treatment Outcome
Wound Healing
X-Rays
