Sex differences in outcomes of sinus surgery. Laryngoscope 2006 Jul;116(7):1199-203
Date
07/11/2006Pubmed ID
16826060DOI
10.1097/01.mlg.0000224575.12945.90Scopus ID
2-s2.0-33747169086 (requires institutional sign-in at Scopus site) 40 CitationsAbstract
PURPOSE: Sex has been demonstrated to affect outcome in many diseases. Our current aim is to investigate the relationship between sex and outcomes of endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis (CRS).
METHODS: Forty-four males and 73 females undergoing ESS for CRS with a mean follow-up of 1.4 years were evaluated prospectively. Computed tomography (CT), endoscopy, and quality of life (QOL) assessment was performed. Univariate analyses were performed to evaluate whether sex was predictive of outcome. Multiple logistic regression analysis was performed to evaluate sex association with patient factors predictive of outcome.
RESULTS: Although no sex differences in CT and endoscopy were observed (CT, P=.107 and endoscopy, P>.1), females consistently scored worse than males on disease-specific QOL pre- and postoperatively. Importantly, there was no effect of sex on improvement/change scores for the QOL instruments. PREDICTIVE MODELS AND MULTIPLE LOGISTIC REGRESSION ANALYSIS: Sex was not found to be predictive of QOL or endoscopic outcome. Female sex was, however, associated with acetylsalicylic acid (ASA) intolerance and depression, both factors that have been associated with poorer outcome.
CONCLUSION: Despite similarities in objective disease measures, females report significantly worse QOL scores pre- and postoperatively. Postoperative improvement did not differ by sex, nor was sex predictive of postoperative outcome. Sex differences in QOL reflect sex differences in ASA intolerance and depression, both more prevalent in females.
Author List
Mendolia-Loffredo S, Laud PW, Sparapani R, Loehrl TA, Smith TLAuthors
Purushottam W. Laud PhD Professor in the Institute for Health and Equity department at Medical College of WisconsinTodd A. Loehrl MD Professor in the Otolaryngology department at Medical College of Wisconsin
Rodney Sparapani PhD Associate Professor in the Institute for Health and Equity department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Chronic DiseaseEndoscopy
Female
Follow-Up Studies
Humans
Incidence
Male
Otorhinolaryngologic Surgical Procedures
Paranasal Sinuses
Postoperative Complications
Postoperative Period
Prospective Studies
Quality of Life
Rhinitis
Risk Factors
Sex Distribution
Sex Factors
Sinusitis
Tomography, X-Ray Computed
United States
