Polymorphism in the interleukin-7 receptor-alpha and outcome after allogeneic hematopoietic cell transplantation with matched unrelated donor. Scand J Immunol 2013 Aug;78(2):214-20
Date
05/23/2013Pubmed ID
23692589Pubmed Central ID
PMC3982186DOI
10.1111/sji.12077Scopus ID
2-s2.0-84880661135 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
Interleukin-7 (IL-7) is essential for T cell development in the thymus and maintenance of peripheral T cells. The α-chain of the IL-7R is polymorphic with the existence of SNPs that give rise to non-synonymous amino acid substitutions. We previously found an association between donor genotypes and increased treatment-related mortality (TRM) (rs1494555G) and acute graft versus host disease (aGvHD) (rs1494555G and rs1494558T) after hematopoietic cell transplantation (HCT). Some studies have confirmed an association between rs6897932C and multiple sclerosis. In this study, we evaluated the prognostic significance of IL-7Rα SNP genotypes in 590-recipient/donor pairs that received HLA-matched unrelated donor HCT for haematological malignancies. Consistent with the primary studies, the rs1494555GG and rs1494558TT genotypes of the donor were associated with aGvHD and chronic GvHD in the univariate analysis. The Tallele of rs6897932 was suggestive of an association with increased frequency of relapse by univariate analysis (P = 0.017) and multivariate analysis (P = 0.015). In conclusion, this study provides further evidence of a role of the IL-7 pathway and IL-7Rα SNPs in HCT.
Author List
Shamim Z, Spellman S, Haagenson M, Wang T, Lee SJ, Ryder LP, Müller KAuthor
Tao Wang PhD Associate Professor in the Institute for Health and Equity department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Acute DiseaseAdolescent
Adult
Alleles
Analysis of Variance
Bone Marrow Transplantation
Chronic Disease
Female
Genotype
Graft vs Host Disease
Hematologic Neoplasms
Histocompatibility Testing
Humans
Male
Middle Aged
Peripheral Blood Stem Cell Transplantation
Polymorphism, Single Nucleotide
Receptors, Interleukin-7
Survival Analysis
Transplantation, Homologous
Treatment Outcome
Unrelated Donors
