Nicotine reverses adult-onset hypothyroidism-induced impairment of learning and memory: Behavioral and electrophysiological studies. J Neurosci Res 2006 Oct;84(5):944-53
Date
08/12/2006Pubmed ID
16902999DOI
10.1002/jnr.21014Scopus ID
2-s2.0-33749487621 (requires institutional sign-in at Scopus site) 60 CitationsAbstract
Nicotine alleviates cognitive impairment associated with a variety of health conditions. We examined the effect of chronic nicotine treatment on adult-onset hypothyroidism-induced impairment of learning and memory in rats. Hypothyroidism was induced by surgical removal of thyroid glands (thyroidectomy). One month later, chronic nicotine treatment (1 mg/kg sc, twice/day) was instituted for 4-6 weeks. Test of hippocampus-dependent spatial learning and memory in the radial arm water maze showed that hypothyroidism impaired learning as well as short-term and long-term memory retention. Chronic nicotine treatment reversed the hypothyroidism-induced learning and memory impairment. In normal rats, chronic nicotine treatment had no effect on learning and memory. Extracellular recordings from the CA1 region of anesthetized hypothyroid rats showed severe reduction of both early-phase and late-phase long-term potentiation (LTP) magnitude, which was reversed in nicotine-treated hypothyroid rats. These results show that chronic nicotine treatment prevents hypothyroidism-induced impairment of spatial cognition and LTP.
Author List
Alzoubi KH, Aleisa AM, Gerges NZ, Alkadhi KAAuthor
Nashaat Gerges PhD Chair, Professor in the School of Pharmacy Administration department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Action PotentialsAnimals
Behavior, Animal
Disease Models, Animal
Dose-Response Relationship, Radiation
Electric Stimulation
Excitatory Postsynaptic Potentials
Hippocampus
Hypothyroidism
Male
Maze Learning
Memory Disorders
Nicotine
Nicotinic Agonists
Rats
Rats, Wistar
Spatial Behavior
Thyroidectomy
Time Factors
