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Early neonatal hypotension in premature infants born to preeclamptic mothers. J Perinatol 2006 Aug;26(8):471-5



Pubmed ID




Scopus ID

2-s2.0-33746526938   11 Citations


BACKGROUND: Early neonatal hypotension (ENH) is common in premature infants and has been claimed to occur more frequently in infants born to mothers with severe preeclampsia. Previous studies that showed a relationship between maternal preeclampsia and neonatal hypotension did not control for potential confounding factors such as birth weight and maternal treatment with magnesium sulfate (MgSO4).

OBJECTIVE: To determine whether maternal preeclampsia is an independent risk factor for ENH.

STUDY DESIGN: We conducted a retrospective review of all viable singleton infants with gestational age of 23 to 30 weeks who were admitted to the neonatal intensive care unit over a 2-year period. ENH was defined as the persistence of the mean arterial pressure lower than the gestational age in weeks requiring volume expansion and inotropic support in the first 24 h of life.

RESULTS: One hundred and eighty four infants were enrolled. Seventy-five (41%) infants met the diagnostic criteria for ENH. Maternal preeclampsia, the presence of labor, maternal treatment with MgSO4, Apgar scores, birth weight, gestational age and respiratory distress syndrome were significantly associated with ENH by univariate analysis. Only gestational age and maternal preeclampsia were significantly associated with ENH by multiple logistic regression.

CONCLUSION: Gestational age and maternal preeclampsia were independent risk factors for ENH in our population of premature infants.

Author List

Teng RJ, Wu TJ, Sharma R, Garrison RD, Hudak ML


Ru-Jeng Teng MD Associate Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Blood Pressure
Gestational Age
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases
Magnesium Sulfate
Risk Factors
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0