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Parental decline of pneumococcal vaccination and risk of pneumococcal related disease in children. Vaccine 2011 Jan 29;29(5):994-9

Date

12/15/2010

Pubmed ID

21145372

Pubmed Central ID

PMC3026079

DOI

10.1016/j.vaccine.2010.11.085

Scopus ID

2-s2.0-78751581787 (requires institutional sign-in at Scopus site)   59 Citations

Abstract

BACKGROUND: An increasing number of parents are choosing to decline immunizations for their children. This study examined the association between the parental decision to decline pneumococcal conjugate (PCV7) vaccinations and the risk of hospitalization due to pneumococcal disease or lobar pneumonia in children.

METHODS: We conducted a case-control study nested within a cohort of children enrolled in the Kaiser Permanente Colorado (KPCO) health plan between 2004 and 2009. Each child hospitalized with pneumococcal disease or lobar pneumonia (n=106) was matched to 4 randomly selected controls (n=401). Cases were matched to controls by age, sex, high-risk status, calendar time, and length of enrollment in KPCO. Disease status and parental vaccination decisions were validated with medical record review. Cases and controls were classified as vaccine decliners or vaccine acceptors.

RESULTS: Among 106 cases, there were 6 (6%) PCV7 vaccine decliners; among 401 controls, there were 4 (1%) vaccine decliners. Children of parents who declined PCV7 immunization were 6.5 times (OR=6.5; 95% CI=1.7, 24.5) more likely to be hospitalized for invasive pneumococcal disease or lobar pneumonia than vaccinated children.

CONCLUSIONS: Parental decline of pneumococcal vaccination apparently increases the risk for hospitalization due to pneumococcal disease or lobar pneumonia in children. Providers can use this information when helping parents weigh the benefits and risks of immunizing their children.

Author List

Glanz JM, McClure DL, O'Leary ST, Narwaney KJ, Magid DJ, Daley MF, Hambidge SJ

Author

David L. McClure PhD Adjunct Assistant Professor in the Institute for Health and Equity department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Case-Control Studies
Child, Preschool
Colorado
Female
Heptavalent Pneumococcal Conjugate Vaccine
Hospitalization
Humans
Infant
Male
Pneumococcal Vaccines
Pneumonia, Pneumococcal
Risk Assessment
Vaccination