Progressive disease in chronic lymphocytic leukemia is correlated with the DNA methylation index. Leuk Res 2007 Jun;31(6):773-7
Date
09/15/2006Pubmed ID
16970987DOI
10.1016/j.leukres.2006.07.007Scopus ID
2-s2.0-34249827572 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
The DNA methylation index (MI) is calculated as a percentage of methylated cytosines to cytosines. We established the DNA MI in 100 normal individuals ranging in age between 1 month and 94 years and found that the age-specific DNA MI can be calculated (4.00-0.0034 x age). We determined the DNA MI in 23 patients with CLL ranging from 47 to 90 years and compared the results with age-matched controls. Using Cox proportional hazard models for MI, adjusting for age and white blood cell count, only the DNA MI correlated with early clinical indications for systemic therapy (p=0.0038, HR=7.00, 95% CI: 1.90-26.20).
Author List
Yu MK, Bergonia H, Szabo A, Phillips JDAuthor
Aniko Szabo PhD Professor in the Institute for Health and Equity department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Age Factors
Aged
Aged, 80 and over
Child
Child, Preschool
DNA Methylation
Disease Progression
Female
Humans
Infant
Leukemia, Lymphocytic, Chronic, B-Cell
Leukocyte Count
Male
Middle Aged
Proportional Hazards Models
