Biological implications of extracellular adenosine in hepatic ischemia and reperfusion injury. Am J Transplant 2013 Oct;13(10):2524-9
Date
08/09/2013Pubmed ID
23924168Pubmed Central ID
PMC3805691DOI
10.1111/ajt.12398Scopus ID
2-s2.0-84884909975 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
The purine nucleoside adenosine is clinically employed in the treatment of supraventricular tachycardia. In addition, it has direct coronary vasodilatory effects, and may influence platelet aggregation. Experimental observations mechanistically link extracellular adenosine to cellular adaptation to hypoxia. Adenosine generation has been implicated in several pathophysiologic processes including angiogenesis, tumor defenses and neurodegeneration. In solid organ transplantation, prolonged tissue ischemia and subsequent reperfusion injury may lead to profound graft dysfunction. Importantly, conditions of limited oxygen availability are associated with increased production of extracellular adenosine and subsequent tissue protection. Within the rapidly expanding field of adenosine biology, several enzymatic steps in adenosine production have been characterized and multiple receptor subtypes have been identified. In this review, we briefly examine the biologic steps involved in adenosine generation and chronicle the current state of adenosine signaling in hepatic ischemia and reperfusion injury.
Author List
Zimmerman MA, Kam I, Eltzschig H, Grenz AMESH terms used to index this publication - Major topics in bold
AdenosineAnimals
Humans
Ischemia
Liver Diseases
Reperfusion Injury
