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Biological implications of extracellular adenosine in hepatic ischemia and reperfusion injury. Am J Transplant 2013 Oct;13(10):2524-9

Date

08/09/2013

Pubmed ID

23924168

Pubmed Central ID

PMC3805691

DOI

10.1111/ajt.12398

Scopus ID

2-s2.0-84884909975   10 Citations

Abstract

The purine nucleoside adenosine is clinically employed in the treatment of supraventricular tachycardia. In addition, it has direct coronary vasodilatory effects, and may influence platelet aggregation. Experimental observations mechanistically link extracellular adenosine to cellular adaptation to hypoxia. Adenosine generation has been implicated in several pathophysiologic processes including angiogenesis, tumor defenses and neurodegeneration. In solid organ transplantation, prolonged tissue ischemia and subsequent reperfusion injury may lead to profound graft dysfunction. Importantly, conditions of limited oxygen availability are associated with increased production of extracellular adenosine and subsequent tissue protection. Within the rapidly expanding field of adenosine biology, several enzymatic steps in adenosine production have been characterized and multiple receptor subtypes have been identified. In this review, we briefly examine the biologic steps involved in adenosine generation and chronicle the current state of adenosine signaling in hepatic ischemia and reperfusion injury.

Author List

Zimmerman MA, Kam I, Eltzschig H, Grenz A

Author

Michael A. Zimmerman MD, FACS Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adenosine
Animals
Humans
Ischemia
Liver Diseases
Reperfusion Injury
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0