The effects of systemic α₁-adrenoreceptor antagonists on pupil diameter. Br J Ophthalmol 2012 Apr;96(4):490-3
Date
10/25/2011Pubmed ID
22021005DOI
10.1136/bjophthalmol-2011-300650Scopus ID
2-s2.0-84858302059 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
AIM: To assess differences in pupil diameter between men taking systemic α(1)-adrenoreceptor antagonists and controls.
SETTING: University of Michigan clinics, USA.
METHODS: Male patients over the age of 50 years were recruited from clinics over 3 months and divided into two groups: 18 study patients taking α(1)-adrenoreceptor antagonists (Flomax, Uroxatral, Cardura and Hytrin) and 31 control patients who had never been on them. Those with conditions known to affect pupil diameter were excluded. Pre-dilation pupil diameters were recorded using a pupillometer in mesopic and scotopic conditions. Right eyes were dilated with phenylephrine and tropicamide, and the left eye served as an undilated control. Following dilation, pupil diameters were measured in both lighting conditions.
RESULTS: No statistically significant difference was found in pupil mydriasis of patients taking α(1)-antagonists versus controls (mesopic p=0.37, scotopic p=0.67). When considering only those patients taking tamsulosin, the lack of significance remained. The duration of time on the medication did not have a statistically significant effect on pupil mydriasis. Comparison of pupil diameters of patients on tamsulosin with those on non-selective α(1)-antagonists, both before and after dilation, showed no significant difference in pupil mydriasis (mesopic p=0.77, scotopic p=1.00).
CONCLUSIONS: The outcomes of this study present an interesting contrast to current literature. Previously, it had been hypothesised that a majority of patients taking α(1)-antagonists would experience preoperative impairment of pupil dilation. The authors found no significant decrease in pupil diameters of patients on α(1)-adrenoreceptor antagonists compared with controls, and no indication that duration or medication subtype had an effect.
Author List
Cooney TM, Wu A, Wilkes G, Finkelstein JI, Musch DCAuthor
Geoffrey Owen Wilkes MD Assistant Professor in the Ophthalmology and Visual Sciences department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adrenergic alpha-1 Receptor AntagonistsAged
Dose-Response Relationship, Drug
Drug Administration Routes
Follow-Up Studies
Humans
Male
Middle Aged
Prostatic Hyperplasia
Pupil
Retrospective Studies
