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Dopamine receptor binding on identified striatonigral neurons. Neurosci Lett 1994 May 19;172(1-2):101-6

Date

05/19/1994

Pubmed ID

8084509

DOI

10.1016/0304-3940(94)90672-6

Scopus ID

2-s2.0-0028289576 (requires institutional sign-in at Scopus site)   13 Citations

Abstract

Dopamine receptors have been divided into two families, known as D1 and D2, based on their ability to bind distinct ligands, and their use of separate post-synaptic transduction systems. Determining the specific cellular location for these dopamine receptors in the striatum is important to the design of drug treatments for disorders with suspected dopaminergic involvement such as Parkinson's disease. This study examined the binding of D1 and D2 antagonist ligands on identified striatonigral neurons using in vitro fluorescent techniques. The results indicate that striatonigral neurons express both pharmacological subfamilies of dopamine receptor binding sites.

Author List

Larson ER, Ariano MA

Author

Eric Larson PhD Associate Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Benzazepines
Fluorescent Dyes
Male
Neostriatum
Neural Pathways
Neurons
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1
Receptors, Dopamine D2
Spectrometry, Fluorescence
Spiperone
Substantia Nigra