Faculty Collaboration Database

2013 report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders. Clin Transpl 2013:187-97

Date

01/01/2013

Pubmed ID

25095508

Scopus ID

2-s2.0-84906956354 (requires institutional sign-in at Scopus site)   48 Citations

Abstract

Data reported herein indicate increasing use of hematopoietic cell transplants for persons with blood and bone marrow disorders. Recent trends include increasing use of alternative donors including human leukocyte antigen (HLA)-matched unrelated persons and HLA-matched umbilical cord blood cells, increasing use of blood cell rather than bone marrow grafts, and increasing use of reduced-intensity pretransplant conditioning regimens. Many of these shifts are driven by logistical considerations such as the need for donors in persons without an HLA-identical sibling or expanding use of allotransplants to older persons. Many changes in transplant practices are not supported by results of large randomized trials. More data are needed to critically-assess the impact of these changes.

Author List

Pasquini M, Wang Z, Horowitz MM, Gale RP

Authors

Mary M. Horowitz MD, MS Professor in the Medicine department at Medical College of Wisconsin
Marcelo C. Pasquini MD, MS Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Bone Marrow Transplantation
Cord Blood Stem Cell Transplantation
Global Health
HLA Antigens
Hematologic Neoplasms
Hematopoietic Stem Cell Transplantation
Histocompatibility
Humans
Survival Rate
Tissue Donors
Transplantation Conditioning
Transplantation, Homologous
Young Adult