The genetic dissection of essential hypertension. Nat Rev Genet 2006 Nov;7(11):829-40
Date
10/13/2006Pubmed ID
17033627DOI
10.1038/nrg1967Scopus ID
2-s2.0-33750202275 (requires institutional sign-in at Scopus site) 241 CitationsAbstract
QTL mapping in humans and rats has identified hundreds of blood-pressure-related phenotypes and genomic regions; the next daunting task is gene identification and validation. The development of novel rat model systems that mimic many elements of the human disease, coupled with advances in the genomic and informatic infrastructure for rats, promise to revolutionize the hunt for genes that determine susceptibility to hypertension. Furthermore, methods are evolving that should enable the identification of candidate genes in human populations. Together with the computational reconstruction of regulatory networks, these methods provide opportunities to significantly advance our understanding of the underlying aetiology of hypertension.
Author List
Cowley AW JrAuthor
Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Chromosome Mapping
Crosses, Genetic
Disease Models, Animal
Founder Effect
Gene Expression Profiling
Genetic Linkage
Humans
Hypertension
Mutation
Quantitative Trait Loci
Rats
Species Specificity
