Effect of obesity on plasma insulin-like growth factor-I in cancer patients. Int J Obes 1991 Aug;15(8):523-7
Date
08/01/1991Pubmed ID
1938095Scopus ID
2-s2.0-0026403567 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
Starvation and malnutrition are associated with low concentrations of plasma insulin-like growth factor I (IGF-I). To evaluate the utility of IGF-I as a screening test for malnutrition, we compared plasma IGF-I concentrations with anthropometric measurements of nutritional status in 99 cancer patients. Forty-three percent of patients were overweight and 4 percent were underweight. Log IGF-I correlated negatively with body weight (r = -0.31, P = 0.002), midarm muscle area (MAMA) (r = -0.31, P = 0.001), triceps skinfold thickness (TSF) (r = -0.24, P = 0.03) and body mass index (r = -0.31, P = 0.003). In males plasma IGF-I correlated with TSF but not MAMA; in females IGF-I correlated with MAMA but not TSF, suggestive of a sexual dimorphism between plasma IGF-I and indices of adiposity. We conclude that obesity was far more prevalent than undernutrition, and that plasma IGF-I correlated negatively with indices of adiposity in a gender specific fashion. Because IGF-I is significantly reduced in the obese as well as in the malnourished, measurements of plasma IGF-I are unlikely to be of adequate clinical specificity to serve as a useful screening test for subtle alterations in nutritional status.
Author List
Colletti RB, Copeland KC, Devlin JT, Roberts JD, McAuliffe TLAuthor
Timothy L. McAuliffe PhD Professor in the Psychiatry and Behavioral Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
Body Mass Index
Female
Humans
Insulin-Like Growth Factor I
Male
Middle Aged
Neoplasms
Nutritional Status
Obesity
Protein-Energy Malnutrition
