Faculty Collaboration Database

Operationalizing proneness to externalizing psychopathology as a multivariate psychophysiological phenotype. Psychophysiology 2011 Jan;48(1):64-72

Date

06/25/2010

Pubmed ID

20573054

Pubmed Central ID

PMC2965823

DOI

10.1111/j.1469-8986.2010.01047.x

Scopus ID

2-s2.0-78650015545 (requires institutional sign-in at Scopus site)   76 Citations

Abstract

The externalizing dimension is viewed as a broad dispositional factor underlying risk for numerous disinhibitory disorders. Prior work has documented deficits in event-related brain potential (ERP) responses in individuals prone to externalizing problems. Here, we constructed a direct physiological index of externalizing vulnerability from three ERP indicators and evaluated its validity in relation to criterion measures in two distinct domains: psychometric and physiological. The index was derived from three ERP measures that covaried in their relations with externalizing proneness-the error-related negativity and two variants of the P3. Scores on this ERP composite predicted psychometric criterion variables and accounted for externalizing-related variance in P3 response from a separate task. These findings illustrate how a diagnostic construct can be operationalized as a composite (multivariate) psychophysiological variable (phenotype).

Author List

Nelson LD, Patrick CJ, Bernat EM

Author

Lindsay D. Nelson PhD Associate Professor in the Neurosurgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Cerebral Cortex
Electroencephalography
Evoked Potentials
Female
Humans
Male
Mental Disorders
Photic Stimulation
Psychiatric Status Rating Scales
Psychometrics
Surveys and Questionnaires