Faculty Collaboration Database

ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature. Mod Pathol 2007 Mar;20(3):310-9

Date

02/06/2007

Pubmed ID

17277765

DOI

10.1038/modpathol.3800742

Scopus ID

2-s2.0-33847375219 (requires institutional sign-in at Scopus site)   92 Citations

Abstract

We report detailed clinical and pathologic features of four cases of anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma (ALK-DLBCL), a rare entity with only 29 currently reported cases. This study is the third largest of all reported series. Biopsies from four adult patients aged 41, 49, 53, and 71 years (three lymph nodes and one nasopharyngeal mass) exhibited immunoblastic/plasmablastic morphology. By immunohistochemistry and/or flow cytometry, they expressed cytoplasmic ALK-1, CD138, VS38 (3/3), monoclonal cytoplasmic light chain, CD45, EMA, CD4, and CD57 (2/3), and were negative for CD3, CD30, CD56, and TIA-1. Two showed variable CD79a expression, and one had rare CD20(+) cells. Two of three cases exhibited rare CD43(+) reactivity. One case showed scattered cytokeratin(+) cells, which could possibly lead to a misdiagnosis of carcinoma. After CHOP and radiotherapy, two stage I patients were free of disease at 58 and 36 months, whereas a stage IV patient was dead of disease at 22 months.

Author List

Reichard KK, McKenna RW, Kroft SH

Author

Steven Howard Kroft MD Chair, Professor in the Pathology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Antigens, CD
Biomarkers, Tumor
Combined Modality Therapy
Female
Flow Cytometry
Humans
Immunohistochemistry
Lymphoma, B-Cell
Lymphoma, Large B-Cell, Diffuse
Male
Middle Aged
Protein-Tyrosine Kinases
Receptor Protein-Tyrosine Kinases