Subsequent donation requests among 2472 unrelated hematopoietic progenitor cell donors are associated with bone marrow harvest. Haematologica 2013 Dec;98(12):1956-63
Date
07/03/2013Pubmed ID
23812935Pubmed Central ID
PMC3856971DOI
10.3324/haematol.2013.088971Scopus ID
2-s2.0-84889791087 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Approximately 1 in 20 unrelated donors are asked to make a second donation of hematopoietic progenitor cells, the majority for the same patient. Anthony Nolan undertook a study of subsequent hematopoietic progenitor cell donations made by its donors from 2005 to 2011, with the aims of predicting those donors more likely to be called for a second donation, assessing rates of serious adverse reactions and examining harvest yields. This was not a study of factors predictive of second allografts. During the study period 2591 donations were made, of which 120 (4.6%) were subsequent donations. The median time between donations was 179 days (range, 21-4016). Indications for a second allogeneic transplant included primary graft failure (11.7%), secondary graft failure (53.2%), relapse (30.6%) and others (1.8%). On multivariate analysis, bone marrow harvest at first donation was associated with subsequent donation requests (odds ratio 2.00, P=0.001). The rate of serious adverse reactions in donors making a subsequent donation appeared greater than the rate in those making a first donation (relative risk=3.29, P=0.005). Harvest yields per kilogram recipient body weight were equivalent between donations, although females appeared to have a lower yield at the subsequent donation. Knowledge of these factors will help unrelated donor registries to counsel their donors.
Author List
Lown RN, Tulpule S, Russell NH, Craddock CF, Roest R, Madrigal JA, Shaw BEAuthor
Bronwen E. Shaw MBChB, PhD Center Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Bone Marrow Transplantation
Child
Child, Preschool
Female
Graft Rejection
Hematopoietic Stem Cell Transplantation
Humans
Infant
Infant, Newborn
Male
Middle Aged
Retrospective Studies
Time Factors
Unrelated Donors
Young Adult
