The clinical implications of HLA mismatches in unrelated donor haematopoietic cell transplantation. Int J Immunogenet 2008 Aug;35(4-5):367-74
Date
11/04/2008Pubmed ID
18976440DOI
10.1111/j.1744-313X.2008.00793.xScopus ID
2-s2.0-52649103908 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
Haematopoietic stem cell transplantation (HSCT), using unrelated donors (UD), is now a common modality of treatment for individuals with a variety of different diseases. HLA matching has been shown to have a significant impact on patient outcome. This study includes 423 unrelated UK patient/donor pairs. The patients and donors were typed at high resolution for HLA-A, -B, -C, -DRB1, -DQB1, -DPB1. The degree and type of HLA mismatch was found to be a significant factor affecting outcome. The matching status for DPB1, both at an allele and epitope level, significantly affected transplant complications. The findings of this study have made it possible to offer advice concerning the choice of the most appropriate unrelated donor to select in order to achieve the best patient outcomes.
Author List
Shaw BEAuthor
Bronwen E. Shaw MBChB, PhD Center Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Alleles
Child
Child, Preschool
Epitopes
Female
Graft vs Host Disease
HLA Antigens
HLA-DP Antigens
HLA-DP beta-Chains
Hematopoietic Stem Cell Transplantation
Histocompatibility Testing
Humans
Infant
Male
Middle Aged
Survival Analysis
Tissue Donors
Young Adult
