Clinical importance of HLA-DPB1 in haematopoietic cell transplantation. Tissue Antigens 2007 Apr;69 Suppl 1:36-41
Date
04/21/2007Pubmed ID
17445160DOI
10.1111/j.1399-0039.2006.759_4.xScopus ID
2-s2.0-34247245373 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
There is increasing evidence for a significant effect of human leukocyte antigen (HLA)-DPB1 mismatching on complications following unrelated donor haematopoietic cell transplantation (HCT). In this analysis of 5930 patient/donor pairs, we found that a DPB1 mismatch predicted significantly for an increased risk of acute graft-vs-host disease [hazard ratio (HR): 1.33; P-value = <0.0001], while protecting against disease relapse (HR: 0.82, P-value = 0.01). These data support an immunogenic role for HLA-DPB1 in HCT and the need for pretransplant tissue typing at this locus.
Author List
Shaw BE, Gooley T, Madrigal JA, Malkki M, Marsh SG, Petersdorf EWAuthor
Bronwen E. Shaw MBChB, PhD Center Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
FemaleGraft vs Host Disease
HLA-DP Antigens
HLA-DP beta-Chains
Hematologic Neoplasms
Hematopoietic Stem Cell Transplantation
Histocompatibility Testing
Humans
Male
Neoplasm Recurrence, Local
Predictive Value of Tests
Survival Rate