Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Clinical importance of HLA-DPB1 in haematopoietic cell transplantation. Tissue Antigens 2007 Apr;69 Suppl 1:36-41

Date

04/21/2007

Pubmed ID

17445160

DOI

10.1111/j.1399-0039.2006.759_4.x

Scopus ID

2-s2.0-34247245373 (requires institutional sign-in at Scopus site)   16 Citations

Abstract

There is increasing evidence for a significant effect of human leukocyte antigen (HLA)-DPB1 mismatching on complications following unrelated donor haematopoietic cell transplantation (HCT). In this analysis of 5930 patient/donor pairs, we found that a DPB1 mismatch predicted significantly for an increased risk of acute graft-vs-host disease [hazard ratio (HR): 1.33; P-value = <0.0001], while protecting against disease relapse (HR: 0.82, P-value = 0.01). These data support an immunogenic role for HLA-DPB1 in HCT and the need for pretransplant tissue typing at this locus.

Author List

Shaw BE, Gooley T, Madrigal JA, Malkki M, Marsh SG, Petersdorf EW

Author

Bronwen E. Shaw MBChB, PhD Center Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Female
Graft vs Host Disease
HLA-DP Antigens
HLA-DP beta-Chains
Hematologic Neoplasms
Hematopoietic Stem Cell Transplantation
Histocompatibility Testing
Humans
Male
Neoplasm Recurrence, Local
Predictive Value of Tests
Survival Rate