Fatal invasive cerebral Absidia corymbifera infection following bone marrow transplantation. Bone Marrow Transplant 2000 Sep;26(6):701-3
Date
10/21/2000Pubmed ID
11041574DOI
10.1038/sj.bmt.1702575Scopus ID
2-s2.0-0033794828 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
A 56-year-old dairy farmer received a fully HLA matched unrelated donor marrow transplant for high risk CML in chronic phase. His early post-transplant course was complicated by a series of massive intracerebral bleeds and by sepsis related to a malignant otitis externa. The microbial pathogen isolated from ear swabs was found to be Absidia corymbifera, but CT scan at the time showed no intracerebral extension. Despite neutrophil engraftment and aggressive antifungal management he succumbed. Autopsy revealed invasion of Absidia into the brain from the ear. We speculate that colonisation by Absidia resulted from occupational exposure.
Author List
Paterson PJ, Marshall SR, Shaw B, Kendra JR, Ethel M, Kibbler CC, Prentice HG, Potter MAuthor
Bronwen E. Shaw MBChB, PhD Center Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AbsidiaBone Marrow Transplantation
Cerebral Hemorrhage
Dairying
Humans
Leukemia, Myeloid, Chronic-Phase
Male
Middle Aged
Mucormycosis
Occupational Exposure
Otitis Externa