Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Is 'informed consent' an 'understood consent' in hematopoietic cell transplantation? Bone Marrow Transplant 2015 Jan;50(1):10-4



Pubmed ID


Pubmed Central ID




Scopus ID

2-s2.0-84920682651   17 Citations


Hematopoietic cell transplantation (HCT) is a complex and highly specialized medical treatment that is associated with significant risks, including death. Furthermore, transplantation is offered to patients who often have no other curative treatment alternatives. The routine-consent process for HCT typically occurs before HCT and is influenced by many factors related to patients, physicians and the transplant per se. These factors can impede the consent process and subsequently result in a failure of proper engagement in and an understanding of the procedure with resultant adverse consequences influencing patients and even the patient-physician relationship. We contend that informed consent is a dynamic and ongoing process and that better patient education can assist in the decision making, fulfill the ethical principle of respect for autonomy and engage the patient to maximize compliance and adherence to therapy. This manuscript reviews the key literature pertaining to the decision-making and consent process in HCT and proposes guidelines for improving the consent process. Strategies for improving patient comprehension, engagement and enhancing consent forms are discussed.

Author List

D'Souza A, Pasquini M, Spellecy R


Anita D'Souza MD Associate Professor in the Medicine department at Medical College of Wisconsin
Marcelo C. Pasquini MD, MS Professor in the Medicine department at Medical College of Wisconsin
Ryan Spellecy PhD Assistant Provost, Director, Professor in the Institute for Health and Equity department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Hematopoietic Stem Cell Transplantation
Informed Consent
Patient Compliance
Physician-Patient Relations
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a