An analysis of pancreas transplantation outcomes based on age groupings--an update of the UNOS database. Clin Transplant 2014 Sep;28(9):990-4
Date
06/24/2014Pubmed ID
24954160DOI
10.1111/ctr.12407Scopus ID
2-s2.0-84908375900 (requires institutional sign-in at Scopus site) 32 CitationsAbstract
INTRODUCTION: Previously, increasing age has been a part of the exclusion criteria used when determining eligibility for a pancreas transplant. However, the analysis of pancreas transplantation outcomes based on age groupings has largely been based on single-center reports.
METHODS: A UNOS database review of all adult pancreas and kidney-pancreas transplants between 1996 and 2012 was performed. Patients were divided into groups based on age categories: 18-29 (n = 1823), 30-39 (n = 7624), 40-49 (n = 7967), 50-59 (n = 3160), and ≥60 (n = 280). We compared survival outcomes and demographic variables between each age grouping.
RESULTS: Of the 20 854 pancreas transplants, 3440 of the recipients were 50 yr of age or above. Graft survival was consistently the greatest in adults 40-49 yr of age. Graft survival was least in adults age 18-29 at one-, three-, and five-yr intervals. At 10- and 15-yr intervals, graft survival was the poorest in adults >60 yr old. Patient survival and age were found to be inversely proportional; as the patient population's age increased, survival decreased.
CONCLUSION: Pancreas transplants performed in patients of increasing age demonstrate decreased patient and graft survival when compared to pancreas transplants in patients <50 yr of age.
Author List
Siskind E, Maloney C, Akerman M, Alex A, Ashburn S, Barlow M, Siskind T, Bhaskaran M, Ali N, Basu A, Molmenti E, Ortiz JAuthor
Caroline Maloney MD, PhD Assistant Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aging
Databases, Factual
Female
Follow-Up Studies
Graft Survival
Humans
Kidney Transplantation
Male
Middle Aged
Pancreas Transplantation
Prognosis
Registries
Tissue Donors
Tissue and Organ Procurement
Young Adult
