Pancreas transplantation from donors after cardiac death: an update of the UNOS database. Pancreas 2014 May;43(4):544-7
Date
03/19/2014Pubmed ID
24632550DOI
10.1097/MPA.0000000000000084Scopus ID
2-s2.0-84898465623 (requires institutional sign-in at Scopus site) 33 CitationsAbstract
OBJECTIVE: There is reluctance to use donation after cardiac death (DCD) organs for fear of worse outcomes due to increased warm ischemia time. Extensive evidence to confirm the quality of DCD pancreas transplants is not manifest.
METHODS: A united network for organ sharing database review of pancreas transplants performed between 1996 and 2012 was conducted. We compared outcomes and all demographic variables between donors after cardiac death and donors after brain death in pancreas transplantation.
RESULTS: There were 320 DCD pancreas transplants and 20,448 donation after brain death pancreas transplants performed in the United States between 1996 and 2012. There was no statistically significant difference in graft survival or patient survival in pancreas transplantation in DCD versus donation after brain death donors measured at 1-year, 3-year, 5-year, 10-year, and 15-year intervals. There was no significant difference between donor and recipient age, race, sex, and body mass index (BMI) between the groups. There was no significant difference between the recipient ethnicity or time on wait list between the groups.
CONCLUSIONS: Pancreata procured by DCD have comparable outcomes to those procured after brain death. Donation after cardiac death pancreas transplant is a viable method of increasing the donor pool, decreasing wait list mortality, and improving the quality of life for type 1 diabetic patients.
Author List
Siskind E, Akerman M, Maloney C, Huntoon K, Alex A, Siskind T, Bhaskeran M, Ali N, Basu A, Molmenti E, Ortiz JAuthor
Caroline Maloney MD, PhD Assistant Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Brain Death
Cause of Death
Databases, Factual
Diabetes Mellitus, Type 1
Female
Heart Diseases
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Pancreas Transplantation
Risk Factors
Time Factors
Tissue Donors
Tissue and Organ Procurement
Treatment Outcome
United States
Waiting Lists
Young Adult