Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Autonomic nervous system evaluation in allergic rhinitis. Otolaryngol Head Neck Surg 2007 Jan;136(1):51-6

Date

01/11/2007

Pubmed ID

17210333

DOI

10.1016/j.otohns.2006.08.014

Scopus ID

2-s2.0-33845915313   24 Citations

Abstract

OBJECTIVES: To evaluate the relationship between allergic rhinitis (AR) and autonomic nervous system (ANS) dysfunction.

METHODS: Quantitative ANS testing was completed in 10 patients with AR confirmed by clinical findings and allergy testing. This data was compared to 16 age-matched controls.

RESULTS: ANS scores were significantly abnormal in AR patients when compared to normal controls. The composite autonomic scale score for the AR group was significantly impaired when compared to controls (1.6 vs 0.63, P < 0.0001). Additionally, subscore values quantifying the level of dysfunction within the sympathetic nervous system (1.0 for sudomotor and 0.5 adrenergic) were found to be significantly different (P < 0.0001 and 0.018). The mean subscore value quantifying the level of dysfunction within the parasympathetic system (cardiovagal) was not found to be significantly different from controls (P = 0.38).

CONCLUSIONS: ANS dysfunction, specifically sympathetic hypofunction, was identified in all of the allergic rhinitis patients studied. Further characterization of the type of ANS abnormality may allow the development of novel pharmacologic therapies for these disorders.

Author List

Ishman SL, Martin TJ, Hambrook DW, Smith TL, Jaradeh SS, Loehrl TA

Author

Todd A. Loehrl MD Professor in the Otolaryngology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Autonomic Nervous System
Female
Humans
Male
Middle Aged
Rhinitis, Allergic, Perennial
jenkins-FCD Prod-478 d1509cf07a111124a2d122fd3df854cc0b993c00