Faculty Collaboration Database

Intertriginous eruption associated with chemotherapy in pediatric patients. Arch Dermatol 2007 Jan;143(1):67-71

Date

01/17/2007

Pubmed ID

17224544

DOI

10.1001/archderm.143.1.67

Scopus ID

2-s2.0-33846449543 (requires institutional sign-in at Scopus site)   17 Citations

Abstract

BACKGROUND: Cutaneous eruptions commonly occur in children receiving chemotherapy, and the clinical situation often demands immediate diagnosis and initiation of treatment. Several patterns of cutaneous eruptions to chemotherapy have been reported; however, the nomenclature used to describe these entities has been derived from the histologic findings. The morphologic characteristics, distribution, and natural history of these reactions have not been well established.

OBSERVATIONS: We report the clinical features of 16 pediatric patients with a distinctive chemotherapy-induced eruption. The eruption is most prominent in or limited to intertriginous regions and areas of occlusion. We were not able to identify any single chemotherapeutic agent or even a group of agents in the same pharmacologic family that seemed to be associated with this reaction. The eruption did not appear to be related to sex, age, ethnicity, underlying malignancy, or genetic disease.

CONCLUSIONS: Recognition of this distinct clinical pattern can help rule out more serious entities, avoid a biopsy, and reassure the physician and patient of the benign and self-resolving clinical course. This entity may be observed with many chemotherapeutic agents and underlying diseases, but most often with high-dose chemotherapy protocols.

Author List

Webber KA, Kos L, Holland KE, Margolis DA, Drolet BA

Authors

Kristen E. Holland MD Associate Professor in the Dermatology department at Medical College of Wisconsin
David A. Margolis MD Interim Chair, Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Abdomen
Adolescent
Antineoplastic Combined Chemotherapy Protocols
Arm
Axilla
Child
Child, Preschool
Drug Eruptions
Female
Groin
Heart Neoplasms
Hemangiosarcoma
Humans
Infant
Intertrigo
Male
Neuroblastoma
Retrospective Studies
Thorax