CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells. PLoS One 2014;9(10):e110731
Date
10/24/2014Pubmed ID
25340755Pubmed Central ID
PMC4207702DOI
10.1371/journal.pone.0110731Scopus ID
2-s2.0-84908448373 (requires institutional sign-in at Scopus site) 82 CitationsAbstract
The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by the lack of a well-accepted assay for quantifying HIV during therapy. We examined the association between multiple measurements of HIV and T cell activation (as defined by markers including CD38, HLA-DR, CCR5 and PD-1) in 30 antiretroviral-treated HIV-infected adults. We found a consistent association between the frequency of CD4+ and CD8+ T cells expressing HLA-DR and the frequency of resting CD4+ T cells containing HIV DNA. This study highlights the need to further examine this relationship and to better characterize the biology of markers commonly used in HIV studies. These results may also have implications for reactivation strategies.
Author List
Cockerham LR, Siliciano JD, Sinclair E, O'Doherty U, Palmer S, Yukl SA, Strain MC, Chomont N, Hecht FM, Siliciano RF, Richman DD, Deeks SGAuthor
Leslie Cockerham MD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
ADP-ribosyl Cyclase 1Adult
Biomarkers
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
DNA, Viral
Disease Reservoirs
Female
HIV Infections
HLA-DR Antigens
Humans
Lymphocyte Activation
Male
Middle Aged
Species Specificity
