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Newborn screening for SCID: where are we now? Expert Rev Clin Immunol 2014 Dec;10(12):1649-57

Date

11/13/2014

Pubmed ID

25387596

DOI

10.1586/1744666X.2014.980816

Scopus ID

2-s2.0-84911169687 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

Newborn screening (NBS) for severe T-cell lymphopenia/severe combined immunodeficiency using the T-cell receptor excision circle assay continues to expand in the USA and worldwide. Here, we will review why severe combined immunodeficiency is an excellent case for NBS, the outcomes of the first 6 years of screening, and dilemmas surrounding screening and management of infants detected by NBS. We will also discuss the future of NBS for primary immunodeficiencies.

Author List

Buelow BJ, Routes JM, Verbsky JW

Authors

Becky J. Buelow MD Associate Professor in the Pediatrics department at Medical College of Wisconsin
James Verbsky MD, PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Early Diagnosis
Humans
Infant, Newborn
Neonatal Screening
Severe Combined Immunodeficiency