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Disrupted small world topology and modular organisation of functional networks in late-life depression with and without amnestic mild cognitive impairment. J Neurol Neurosurg Psychiatry 2015 Oct;86(10):1097-105

Date

11/30/2014

Pubmed ID

25433036

Pubmed Central ID

PMC4465874

DOI

10.1136/jnnp-2014-309180

Scopus ID

2-s2.0-84942234881   40 Citations

Abstract

BACKGROUND: The topological architecture of the whole-brain functional networks in those with and without late-life depression (LLD) and amnestic mild cognitive impairment (aMCI) are unknown.

AIMS: To investigate the differences in the small-world measures and the modular community structure of the functional networks between patients with LLD and aMCI when occurring alone or in combination and cognitively healthy non-depressed controls.

METHODS: 79 elderly participants (LLD (n=23), aMCI (n=18), comorbid LLD and aMCI (n=13), and controls (n=25)) completed neuropsychiatric assessments. Graph theoretical methods were employed on resting-state functional connectivity MRI data.

RESULTS: LLD and aMCI comorbidity was associated with the greatest disruptions in functional integration measures (decreased global efficiency and increased path length); both LLD groups showed abnormal functional segregation (reduced local efficiency). The modular network organisation was most variable in the comorbid group, followed by patients with LLD-only. Decreased mean global, local and nodal efficiency metrics were associated with greater depressive symptom severity but not memory performance.

CONCLUSIONS: Considering the whole brain as a complex network may provide unique insights on the neurobiological underpinnings of LLD with and without cognitive impairment.

Author List

Li W, Douglas Ward B, Liu X, Chen G, Jones JL, Antuono PG, Li SJ, Goveas JS

Authors

Piero G. Antuono MD Professor in the Neurology department at Medical College of Wisconsin
Joseph S. Goveas MD Professor in the Psychiatry department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aged
Antidepressive Agents
Brain
Cognition Disorders
Cognitive Dysfunction
Depressive Disorder
Female
Humans
Magnetic Resonance Imaging
Male
Nerve Net
Nootropic Agents
Psychiatric Status Rating Scales