High density lipoprotein biogenesis, cholesterol efflux, and immune cell function. Arterioscler Thromb Vasc Biol 2012 Nov;32(11):2561-5
Date
10/19/2012Pubmed ID
23077142Pubmed Central ID
PMC3793253DOI
10.1161/ATVBAHA.112.300135Scopus ID
2-s2.0-84871865547 (requires institutional sign-in at Scopus site) 84 CitationsAbstract
This review provides a summary of recent research on the role of high-density lipoprotein (HDL)/apolipoprotein A-I cholesterol efflux and immune cell function. Plasma concentrations of HDL have been known to inversely correlate with risk for coronary vascular disease. Bulk transport of HDL cholesterol from the peripheral tissues to the liver is a major pathway, termed reverse cholesterol transport, responsible for maintaining whole body cholesterol homeostasis. In addition to participating in this pathway, HDL and apolipoprotein A-I exert anti-inflammatory effects through different pathways. One pathway that seems to be important in atherosclerosis and autoimmunity is its role in modulation of T cell activation. HDL/apolipoprotein A-I helps regulate cell signaling by accepting membrane cholesterol from ATP binding cassette transporter A1 on immune cells and, thereby, fine tuning the amount of cholesterol present in plasma membrane lipid rafts.
Author List
Sorci-Thomas MG, Thomas MJAuthors
Mary Sorci Thomas PhD Professor in the Medicine department at Medical College of WisconsinMichael J. Thomas PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
ATP Binding Cassette Transporter 1ATP-Binding Cassette Transporters
Animals
Apolipoprotein A-I
Atherosclerosis
Autoimmunity
Biological Transport
Cholesterol
Homeostasis
Humans
Inflammation
Lipoproteins, HDL
Lymphocyte Activation
Lysophospholipids
Membrane Microdomains
Sphingosine
T-Lymphocytes
