Fatty acid synthase is required for mammary gland development and milk production during lactation. Am J Physiol Endocrinol Metab 2014 May 15;306(10):E1132-43
Date
03/29/2014Pubmed ID
24668799Pubmed Central ID
PMC4116404DOI
10.1152/ajpendo.00514.2013Scopus ID
2-s2.0-84900561409 (requires institutional sign-in at Scopus site) 56 CitationsAbstract
The mammary gland is one of the few adult tissues that strongly induce de novo fatty acid synthesis upon physiological stimulation, suggesting that fatty acid is important for milk production during lactation. The committed enzyme to perform this function is fatty acid synthase (FASN). To determine whether de novo fatty acid synthesis is obligatory or dietary fat is sufficient for mammary gland development and function during lactation, Fasn was specifically knocked out in mouse mammary epithelial cells. We found that deletion of Fasn hindered the development and induced the premature involution of the lactating mammary gland and significantly decreased medium- and long-chain fatty acids and total fatty acid contents in the milk. Consequently, pups nursing from Fasn knockout mothers experienced growth retardation and preweanling death, which was rescued by cross-fostering pups to a lactating wild-type mother. These results demonstrate that FASN is essential for the development, functional competence, and maintenance of the lactating mammary gland.
Author List
Suburu J, Shi L, Wu J, Wang S, Samuel M, Thomas MJ, Kock ND, Yang G, Kridel S, Chen YQAuthor
Michael J. Thomas PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAnimals, Newborn
Fatty Acid Synthase, Type I
Female
Lactation
Male
Mammary Glands, Animal
Mice
Mice, Knockout
Milk
