Impact of sperm morphology on the likelihood of pregnancy after intrauterine insemination. Fertil Steril 2014 Dec;102(6):1584-90.e2
Date
12/03/2014Pubmed ID
25439801DOI
10.1016/j.fertnstert.2014.09.016Scopus ID
2-s2.0-84921973737 (requires institutional sign-in at Scopus site) 34 CitationsAbstract
OBJECTIVE: To determine whether there is a difference in ongoing pregnancy rates (PRs) between patients undergoing IUI with strict sperm morphology ≤4% compared with >4% on initial semen analysis.
DESIGN: Retrospective chart review with multivariate analysis.
SETTING: Academic outpatient reproductive center.
PATIENT(S): A total of 408 couples with male and/or female factor infertility and known strict sperm morphology (SSM).
INTERVENTION(S): A total of 856 IUIs with partner's sperm (IUI-P).
MAIN OUTCOME MEASURE(S): Ongoing PRs based on ultrasound documentation of intrauterine pregnancy with fetal heart tones.
RESULT(S): There is no statistically significant difference in per cycle PRs when comparing patients with a strict sperm morphology of ≤4% versus >4% who undergo IUI-P (17.3% vs. 16.7%; odds ratio 0.954, 95% confidence interval 0.66-1.37). Multiple potential confounding factors were assessed using multivariate analysis.
CONCLUSION(S): Strict sperm morphology ≤4% is not associated with lower PRs in couples undergoing IUI-P, and thus should not be the sole reason for advancing to IVF.
Author List
Deveneau NE, Sinno O, Krause M, Eastwood D, Sandlow JI, Robb P, Granlund A, Strawn EY JrAuthor
Jay I. Sandlow MD Chair, Professor in the Urologic Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultFemale
Humans
Infertility, Male
Insemination
Insemination, Artificial, Homologous
Male
Pregnancy
Pregnancy Rate
Retrospective Studies
Spermatozoa
Varicocele
