Faculty Collaboration Database

Predonation health-related quality of life scores predict time to recovery in hematopoietic stem cell donors. Biol Blood Marrow Transplant 2015 Feb;21(2):350-6

Date

12/03/2014

Pubmed ID

25452034

DOI

10.1016/j.bbmt.2014.10.028

Scopus ID

2-s2.0-84920923387 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

The physical reactions to hematopoietic stem cell donation have been extensively studied, but less is known about factors that predict poorer donation experiences. The aim of this prospective study was to examine demographic and health-related quality of life (HRQOL) factors that might be associated with recovery and side effects. We also described the changes in HRQOL during the donation process. In total, 275 peripheral blood stem cell (PBSC) and 37 bone marrow (BM) consecutive donors completed the SF-36 questionnaire predonation and 4 weeks, and 3 months postdonation. Predonation HRQOL markers were the strongest predictors of time to recovery. Poorer predonation physical health was associated with longer recovery (P = .017) and certain side effects in PBSC donors. Poorer predonation mental health was associated with longer recovery in BM donors (P = .03) and pain after PBSC donation (P = .003). Physical HRQOL scores declined significantly from predonation to 4 weeks postdonation. This was shown both for PBSC and BM donors (P < .001 and P = .009, respectively), but the decline was much greater for BM donors. There was a return to predonation HRQOL values 3 months after donation in both groups with values well above the mean of the general population (P < .001).

Author List

Billen A, Madrigal JA, Strydom A, Szydlo RM, Switzer GE, Shaw BE

Author

Bronwen E. Shaw MBChB, PhD Center Director, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Bone Marrow Transplantation
Convalescence
Female
Hematopoietic Stem Cell Mobilization
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
Humans
Male
Mental Health
Middle Aged
Pain
Peripheral Blood Stem Cell Transplantation
Prospective Studies
Quality of Life
Research Design
Surveys and Questionnaires
Time Factors
Tissue Donors