Faculty Collaboration Database

The impact of improved JACIE standards on the care of related BM and PBSC donors. Bone Marrow Transplant 2015 Feb;50(2):244-7

Date

11/12/2014

Pubmed ID

25387092

DOI

10.1038/bmt.2014.260

Scopus ID

2-s2.0-84922410998 (requires institutional sign-in at Scopus site)   18 Citations

Abstract

Discrepancies exist between the care of unrelated donors (UDs) and related donors (RDs), particularly regarding medical suitability criteria, consenting procedures and donor follow-up. Changes to the most recent JACIE standards have addressed these issues. We studied 208 RDs who underwent PBSC or BM donation in a single centre during 2004-2013 to determine the impact of regulatory changes on donor care, and assessed the safety and efficacy of stem cell donation in donors not meeting UD medical suitability criteria. We observed significant improvements in donor consenting procedures (P=0.003) and donor follow-up (P=0.007) after stipulations in these areas were introduced. We saw a higher incidence of serious adverse events (SAEs) in RDs not meeting UD suitability criteria (P=0.018), and a higher incidence of SAEs in donors ⩾60 years (P=0.020). Haematopoietic progenitor cell donation is less safe in RDs who do not meet UD criteria for medical suitability. Although changes to JACIE standards have improved practice, development of specific medical suitability for RDs and guidelines around 'grey areas' where risks to a donor are unclear or theoretical, will be important in improving RD safety and standardising practice.

Author List

Anthias C, Ethell ME, Potter MN, Madrigal A, Shaw BE

Author

Bronwen E. Shaw MBChB, PhD Center Director, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Bone Marrow
Donor Selection
Humans
Middle Aged
Peripheral Blood Stem Cell Transplantation
Unrelated Donors