Faculty Collaboration Database

Lymphotoxin-alpha and galectin-2 SNPs are not associated with myocardial infarction in two different German populations. J Mol Med (Berl) 2007 Sep;85(9):997-1004

Date

05/15/2007

Pubmed ID

17497114

DOI

10.1007/s00109-007-0211-4

Scopus ID

2-s2.0-34547848794 (requires institutional sign-in at Scopus site)   22 Citations

Abstract

Recent data provided strong evidence for the association of single nucleotide polymorphisms (SNPs) in the lymphotoxin-alpha (LTA) and galectin-2 (LGALS2) genes with myocardial infarction (MI) in a Japanese population. For populations of other genetic background, the relevance of these polymorphisms in the pathogenesis of MI remains controversial. We aimed to define the role of LTA and LGALS2 SNPs in two German MI populations with markedly different ascertainment strategies. Two different MI populations were studied. In the first population, MI patients were ascertained by a strong family history of MI (n = 1214). Controls were unrelated disease-free participants of the study (n = 1080). The second population included patients suffering from sporadic (nonfamilial) MI from the German KORA register (n = 607). The control group consisted of participants of the WHO MONICA survey in Germany (n = 1492). TaqMan assays were used to determine the genotypes of 4 SNPs in the LTA genomic region and 1 SNP in the LGALS2 gene. Single SNPs in both genomic regions as well as haplotypes in the LTA genomic region were tested for association in various models of inheritance. No association with MI could be found for any of the examined SNPs in the LTA genomic region and LGALS2 gene, or for haplotypes spanning the LTA genomic region. In two MI populations of European descent with markedly different ascertainment strategies, we were not able to identify a significant association of SNPs in the LTA genomic region or the LGALS2 gene with MI. These variants are unlikely to play a significant role in populations of European origin.

Author List

Sedlacek K, Neureuther K, Mueller JC, Stark K, Fischer M, Baessler A, Reinhard W, Broeckel U, Lieb W, Erdmann J, Schunkert H, Riegger G, Illig T, Meitinger T, Hengstenberg C

Author

Ulrich Broeckel MD Chief, Center Associate Director, Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
DNA Mutational Analysis
Female
Galectin 2
Gene Frequency
Genetic Predisposition to Disease
Genotype
Germany
Haplotypes
Humans
Lymphotoxin-alpha
Male
Middle Aged
Myocardial Infarction
Polymerase Chain Reaction
Polymorphism, Single Nucleotide