Faculty Collaboration Database

Time course of semantic processes during sentence comprehension: an fMRI study. Neuroimage 2007 Jul 01;36(3):924-32

Date

05/15/2007

Pubmed ID

17500009

Pubmed Central ID

PMC1941617

DOI

10.1016/j.neuroimage.2007.03.059

Scopus ID

2-s2.0-34250311292 (requires institutional sign-in at Scopus site)   162 Citations

Abstract

The ability to create new meanings from combinations of words is one important function of the language system. We investigated the neural correlates of combinatorial semantic processing using fMRI. During scanning, participants performed a rating task on auditory word or pseudoword strings that differed in the presence of combinatorial and word-level semantic information. Stimuli included normal sentences comprised of thematically related words that could be readily combined to produce a more complex meaning, semantically incongruent sentences in which content words were randomly replaced with other content words, pseudoword sentences, and versions of these three sentence types in which syntactic structure was removed by randomly re-ordering the words. Several regions showed greater BOLD signal for stimuli with words than for those with pseudowords, including the left angular gyrus, left superior temporal sulcus, and left inferior frontal gyrus, suggesting that these areas are involved in semantic access at the single word level. In the angular and inferior frontal gyri these differences emerged early in the course of the hemodynamic response. An effect of combinatorial semantic structure was observed in the left angular gyrus and left lateral temporal lobe, which showed greater activation for normal compared to semantically incongruent sentences. These effects appeared later in the time course of the hemodynamic response, beginning after the entire stimulus had been presented. The data indicate a complex spatiotemporal pattern of activity associated with computation of word and sentence-level semantic information, and suggest a particular role for the left angular gyrus in processing overall sentence meaning.

Author List

Humphries C, Binder JR, Medler DA, Liebenthal E

Author

Jeffrey R. Binder MD Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Brain
Brain Mapping
Female
Humans
Language
Magnetic Resonance Imaging
Male
Mental Processes
Middle Aged
Oxygen
Reading
Regression Analysis
Semantics