Biomechanical correlates of mild diffuse brain injury in the rat. Biomed Sci Instrum 2007;43:18-23
Date
05/10/2007Pubmed ID
17487051Scopus ID
2-s2.0-34247586519 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
The relationship between diffuse brain injury (DBI) occurrence and impact biomechanics is well documented. Previous studies attempted to develop injury thresholds based on various biomechanical parameters and have demonstrated inconsistent results. The spectral nature of DBI requires robust metrics capable of predicting injury occurrence and severity. In the present study impact biomechanics reported previously were correlated to rat unconsciousness time. Significant correlation was identified in three parameters including square angular velocity, change in rotational velocity, and Head Impact Power. Results suggest rotational loading of the rat head has similar correlates to the human condition. In addition, certain biomechanical parameters demonstrate capacity for predicting DBI severity.
Author List
Fijalkowski RJ, Stemper BD, Pintar FA, Yoganandan N, Gennarelli TAAuthors
Frank A. Pintar PhD Chair, Professor in the Biomedical Engineering department at Medical College of WisconsinBrian Stemper PhD Professor in the Biomedical Engineering department at Medical College of Wisconsin
Narayan Yoganandan PhD Professor in the Neurosurgery department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AccelerationAnimals
Biomechanical Phenomena
Brain
Brain Injuries
Computer Simulation
Head Movements
Male
Models, Biological
Physical Stimulation
Rats
Rats, Sprague-Dawley
Severity of Illness Index
Unconsciousness
Wounds, Nonpenetrating
