Radiative transport-based frequency-domain fluorescence tomography. Phys Med Biol 2008 Apr 21;53(8):2069-88
Date
03/28/2008Pubmed ID
18364555Pubmed Central ID
PMC3166518DOI
10.1088/0031-9155/53/8/005Scopus ID
2-s2.0-42649103988 (requires institutional sign-in at Scopus site) 70 CitationsAbstract
We report the development of radiative transport model-based fluorescence optical tomography from frequency-domain boundary measurements. The coupled radiative transport model for describing NIR fluorescence propagation in tissue is solved by a novel software based on the established Attila particle transport simulation platform. The proposed scheme enables the prediction of fluorescence measurements with non-contact sources and detectors at a minimal computational cost. An adjoint transport solution-based fluorescence tomography algorithm is implemented on dual grids to efficiently assemble the measurement sensitivity Jacobian matrix. Finally, we demonstrate fluorescence tomography on a realistic computational mouse model to locate nM to microM fluorophore concentration distributions in simulated mouse organs.
Author List
Joshi A, Rasmussen JC, Sevick-Muraca EM, Wareing TA, McGhee JAuthor
Amit Joshi PhD Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AlgorithmsAnimals
Diagnostic Imaging
Equipment Design
Fluorescence
Image Processing, Computer-Assisted
Kidney
Mice
Pattern Recognition, Automated
Phantoms, Imaging
Scattering, Radiation
Signal Processing, Computer-Assisted
Software
Spectroscopy, Near-Infrared
Tomography, Optical
