Neural systemic impairment from whole-body vibration. J Neurosci Res 2015 May;93(5):736-44
Date
01/06/2015Pubmed ID
25557339DOI
10.1002/jnr.23536Scopus ID
2-s2.0-84925682953 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
Insidious brain microinjury from motor vehicle-induced whole-body vibration (WBV) has not yet been investigated. For a long time we have believed that WBV would cause cumulative brain microinjury and impair cerebral function, which suggests an important risk factor for motor vehicle accidents and secondary cerebral vascular diseases. Fifty-six Sprague-Dawley rats were divided into seven groups (n = 8): 1) 2-week normal control group, 2) 2-week sham control group (restrained in the tube without vibration), 3) 2-week vibration group (exposed to whole-body vibration at 30 Hz and 0.5g acceleration for 4 hr/day, 5 days/week, for 2 weeks), 4) 4-week sham control group, 5) 4-week vibration group, 6) 8-week sham control group, and 7) 8-week vibration group. At the end point, all rats were evaluated in behavior, physiological, and brain histopathological studies. The cerebral injury from WBV is a cumulative process starting with vasospasm squeezing of the endothelial cells, followed by constriction of the cerebral arteries. After the 4-week vibration, brain neuron apoptosis started. After the 8-week vibration, vacuoles increased further in the brain arteries. Brain capillary walls thickened, mean neuron size was obviously reduced, neuron necrosis became prominent, and wide-ranging chronic cerebral edema was seen. These pathological findings are strongly correlated with neural functional impairments.
Author List
Yan JG, Zhang LL, Agresti M, LoGiudice J, Sanger JR, Matloub HS, Havlik RAuthors
Robert Havlik MD Chair, Professor in the Plastic Surgery department at Medical College of WisconsinJohn A. LoGiudice MD Professor in the Plastic Surgery department at Medical College of Wisconsin
Hani S. Matloub MD Professor in the Plastic Surgery department at Medical College of Wisconsin
James R. Sanger MD Professor in the Plastic Surgery department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Analysis of VarianceAnimals
Cerebral Cortex
Disease Models, Animal
Hindlimb Suspension
Male
Maze Learning
Microscopy, Electron, Transmission
Middle Cerebral Artery
Muscle Strength
Nervous System Diseases
Neural Conduction
Neurons
Nitric Oxide
Oxygen
Pain Measurement
Rats
Rats, Sprague-Dawley
Vibration
