Faculty Collaboration Database

Connexin-related (DFNB1) hearing loss: is routine computed tomography imaging necessary? Otolaryngol Head Neck Surg 2015 May;152(5):889-96

Date

01/15/2015

Pubmed ID

25583854

DOI

10.1177/0194599814566399

Scopus ID

2-s2.0-84930710315 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

OBJECTIVES: Determine if routine computed tomography (CT) imaging is necessary in the workup for children with connexin-related (DFNB1) sensorineural hearing loss (SNHL).

STUDY DESIGN: Case-control retrospective chart and imaging review.

SETTING: Tertiary care otolaryngology practice.

SUBJECTS AND METHODS: High-resolution temporal bone CT scans of children (n = 21) with DFNB1 SNHL were compared to age-matched controls with either conductive hearing loss (CHL, n = 33) or a nonsyndromic, non-DFNB1 SNHL (n = 33). Sixteen measurements of cochleo-vestibular structures were recorded. Statistical analysis was performed using a repeated analysis of variance model that controlled for both age and gender. Area under the curve (AUC) and multidimensional AUC (MAUC) analyses were also performed.

RESULTS: Overall, no statistically significant differences were found between the 3 experimental groups. In addition, comparisons between the DFNB1 and CHL groups, DFNB1 and non-DFNB1 SNHL groups, and CHL and non-DFNB1 SNHL groups failed to demonstrate any statistically significant differences. AUC and MAUC analyses also failed to detect any significant differences between the 3 groups.

CONCLUSIONS: Patients with DFNB1 SNHL do not have significant anatomic differences on temporal bone CT scans when compared to non-DFNB1 SNHL and CHL control groups. Based on the above analysis, it is reasonable to avoid routine CT imaging of the temporal bones in children with known DFNB1 SNHL unless otherwise clinically indicated.

Author List

Dahl JP, Stadler ME, Huang BY, Miao D, Patel MR, Adunka OF, Buchman CA, Fine JP, Zdanski CJ

Author

Michael Stadler MD Associate Dean, Chief Medical Officer, Associate P in the Medical College Physicians Administration department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Child
Child, Preschool
Connexin 26
Connexins
DNA Mutational Analysis
Female
Hearing Loss, Sensorineural
Humans
Infant
Male
Retrospective Studies
Temporal Bone
Tomography, X-Ray Computed