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T-cell/histiocyte-rich large B-cell lymphoma in pediatric patients: an under-recognized entity? Ann Clin Lab Sci 2015;45(1):73-8

Date

02/20/2015

Pubmed ID

25696014

Scopus ID

2-s2.0-84923113815 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a distinct subtype of diffuse large B-cell lymphoma (DLBCL) under-recognized in the pediatric population. A meticulous workup is necessary to avoid a misdiagnosis of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) or classical Hodgkin lymphoma (HL). A strong degree of suspicion and an emphasis on immunohistochemical staining are required to reach the diagnosis. Few children with advanced stage disease have been described to date. We report two pediatric patients with high stage THRLBCL and highlight their clinical and pathological features.

Author List

Gheorghe G, Rangarajan HG, Camitta B, Segura A, Kroft S, Southern JF

Authors

Steven Howard Kroft MD Chair, Professor in the Pathology department at Medical College of Wisconsin
Annette D. Segura MD Adjunct Assistant Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Child
Female
Histiocytes
Humans
Lymphoma, B-Cell
Magnetic Resonance Imaging
Male
Paraspinal Muscles
Spine
T-Lymphocytes