T-cell/histiocyte-rich large B-cell lymphoma in pediatric patients: an under-recognized entity? Ann Clin Lab Sci 2015;45(1):73-8
Date
02/20/2015Pubmed ID
25696014Scopus ID
2-s2.0-84923113815 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a distinct subtype of diffuse large B-cell lymphoma (DLBCL) under-recognized in the pediatric population. A meticulous workup is necessary to avoid a misdiagnosis of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) or classical Hodgkin lymphoma (HL). A strong degree of suspicion and an emphasis on immunohistochemical staining are required to reach the diagnosis. Few children with advanced stage disease have been described to date. We report two pediatric patients with high stage THRLBCL and highlight their clinical and pathological features.
Author List
Gheorghe G, Rangarajan HG, Camitta B, Segura A, Kroft S, Southern JFAuthors
Steven Howard Kroft MD Chair, Professor in the Pathology department at Medical College of WisconsinAnnette D. Segura MD Adjunct Assistant Professor in the Pathology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdolescentChild
Female
Histiocytes
Humans
Lymphoma, B-Cell
Magnetic Resonance Imaging
Male
Paraspinal Muscles
Spine
T-Lymphocytes