Faculty Collaboration Database

In vitro oxidation of low-density lipoprotein in two species of nonhuman primates subjected to caloric restriction. J Gerontol A Biol Sci Med Sci 2000 Jul;55(7):B355-61

Date

07/18/2000

Pubmed ID

10898249

DOI

10.1093/gerona/55.7.b355

Scopus ID

2-s2.0-0033922904 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

Caloric restriction (CR), which increases longevity and retards age-associated diseases in laboratory rodents, is being evaluated in nonhuman primate trials. CR reduces oxidative stress in rodents and appears to improve risk factors for cardiovascular disease in nonhuman primates. We tested the hypothesis that low-density lipoprotein (LDL) oxidizability is reduced in two monkey species (rhesus and cynomolgus) subjected to chronic CR. In both species, no significant differences occurred between CR and control animals on total, LDL, or high-density lipoprotein (HDL) cholesterol. In rhesus monkeys, triglycerides were higher in controls than CR (139 +/- 23 vs 66 +/- 8 mg/dl,p < .01, respectively). LDL from CR rhesus monkeys was reduced in triglyceride content and molecular weight compared to controls, whereas LDL composition in cynomolgus monkeys was similar in CR and control animals. In keeping with minor deviations in lipids, antioxidants, and LDL composition, no consistent differences in in vitro LDL oxidizability were apparent between CR and controls in either species.

Author List

Cefalu WT, Terry JG, Thomas MJ, Morgan TM, Edwards IJ, Rudel LL, Kemnitz JW, Weindruch R

Author

Michael J. Thomas PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Cholesterol, HDL
Cholesterol, LDL
Energy Intake
Female
In Vitro Techniques
Lipids
Lipoproteins, LDL
Macaca fascicularis
Macaca mulatta
Male
Oxidation-Reduction
Oxidative Stress
Triglycerides
Vitamin E