Medical College of Wisconsin
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Physiological aspects of low-density lipoprotein oxidation. Curr Opin Lipidol 2000 Jun;11(3):297-301

Date

07/06/2000

Pubmed ID

10882346

DOI

10.1097/00041433-200006000-00011

Scopus ID

2-s2.0-0034040275 (requires institutional sign-in at Scopus site)   21 Citations

Abstract

The oxidation of LDL is thought to be a major contributor to the development of atherosclerosis. Considerable descriptive evidence has been accumulated showing that oxidized LDL promotes pro-atherogenic events. However, direct evidence that oxidized LDL causes atherosclerosis is lacking. This article summarizes the results of recent studies that demonstrate how oxidized LDL affects cellular function, and highlights key issues that should be addressed to link LDL oxidation with atherosclerosis.

Author List

Thomas MJ

Author

Michael J. Thomas PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Apoptosis
Arteriosclerosis
Lipoproteins, LDL
Mice
Mice, Transgenic
Models, Biological
Nitric Oxide
Vitamin E