Physiological aspects of low-density lipoprotein oxidation. Curr Opin Lipidol 2000 Jun;11(3):297-301
Date
07/06/2000Pubmed ID
10882346DOI
10.1097/00041433-200006000-00011Scopus ID
2-s2.0-0034040275 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
The oxidation of LDL is thought to be a major contributor to the development of atherosclerosis. Considerable descriptive evidence has been accumulated showing that oxidized LDL promotes pro-atherogenic events. However, direct evidence that oxidized LDL causes atherosclerosis is lacking. This article summarizes the results of recent studies that demonstrate how oxidized LDL affects cellular function, and highlights key issues that should be addressed to link LDL oxidation with atherosclerosis.
Author List
Thomas MJAuthor
Michael J. Thomas PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsApoptosis
Arteriosclerosis
Lipoproteins, LDL
Mice
Mice, Transgenic
Models, Biological
Nitric Oxide
Vitamin E