Faculty Collaboration Database

Dietary fatty acids, low density lipoprotein composition and oxidation and primate atherosclerosis. J Nutr 1996 Apr;126(4 Suppl):1058S-62S

Date

04/01/1996

Pubmed ID

8642432

DOI

10.1093/jn/126.suppl_4.1058S

Scopus ID

2-s2.0-0030008094 (requires institutional sign-in at Scopus site)   26 Citations

Abstract

Low density lipoproteins (LDL) were isolated from nonhuman primates fed isocaloric diets rich in different types of fatty acids. These diets contained 35% of calories as fat enriched in fatty acids from the following sources: lard that is rich in saturated fatty acids, safflower oil rich in oleic acid, safflower oil rich in linoleic acid and menhaden oil that is rich in n-3 fatty acids. LDL composition reflected the dietary fats. LDL were subjected to oxidation using copper ions and azobis(2-amidinopropane) x 2HCl. In general, the sensitivity of LDL to oxidation depended on both the poly-unsaturated fatty acid and vitamin E content. However, the lag times calculated for the copper ion catalyzed oxidations did not show the linear dependence on vitamin E content that was found for azobis(2-amidinopropane) catalyzed oxidation.

Author List

Thomas MJ, Rudel LL

Author

Michael J. Thomas PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Arteriosclerosis
Dietary Fats
Fatty Acids
Lipoproteins, LDL
Macaca fascicularis
Oxidation-Reduction
Vitamin E