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Release of aldehydes from rat alveolar macrophages exposed in vitro to low concentrations of nitrogen dioxide. Biochim Biophys Acta 1995 Jun 06;1256(3):334-40

Date

06/06/1995

Pubmed ID

7786896

DOI

10.1016/0005-2760(95)00041-a

Scopus ID

2-s2.0-0029035346 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

This study demonstrated that aldehydes are released into the extracellular medium when alveolar macrophages (AM) are exposed to nitrogen dioxide (NO2) at concentrations that impair cell function but do not cause cell death. Butanal, glycolaldehyde, 4-hydroxynonenal, pentanal, pentenal, and hexanal were found. Dinitrophenylhydrazine (DNP) derivitization, thin layer chromatography, high performance liquid chromatography, and gas chromatography-mass spectrometry were used to identify the products. Some of the aldehydes have potential toxicity and may be responsible, in part, for altered AM function observed following NO2 exposure.

Author List

Robison TW, Forman HJ, Thomas MJ

Author

Michael J. Thomas PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aldehydes
Animals
Chromatography, Thin Layer
Gas Chromatography-Mass Spectrometry
In Vitro Techniques
Macrophages, Alveolar
Male
Nitrogen Dioxide
Phenylhydrazines
Rats
Rats, Sprague-Dawley
Respiratory Burst