Urate causes the human polymorphonuclear leukocyte to secrete superoxide. Free Radic Biol Med 1992;12(1):89-91
Date
01/01/1992Pubmed ID
1311281DOI
10.1016/0891-5849(92)90061-kScopus ID
2-s2.0-0026505065 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
The human polymorphonuclear leukocyte generates O2-. and H2O2 when it is treated with uric acid. A transition metal catalyzed reaction between O2-. and H2O2 can give the hydroxyl radical and myeloperoxidase forms hypochlorous acid from H2O2 and chloride. Therefore, the uric acid-induced secretion of oxidants may be responsible for a large part of the inflammation associated with gout.
Author List
Thomas MJAuthor
Michael J. Thomas PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Free RadicalsHumans
Neutrophils
Superoxides
Uric Acid