Medical College of Wisconsin
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Urate causes the human polymorphonuclear leukocyte to secrete superoxide. Free Radic Biol Med 1992;12(1):89-91

Date

01/01/1992

Pubmed ID

1311281

DOI

10.1016/0891-5849(92)90061-k

Scopus ID

2-s2.0-0026505065 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

The human polymorphonuclear leukocyte generates O2-. and H2O2 when it is treated with uric acid. A transition metal catalyzed reaction between O2-. and H2O2 can give the hydroxyl radical and myeloperoxidase forms hypochlorous acid from H2O2 and chloride. Therefore, the uric acid-induced secretion of oxidants may be responsible for a large part of the inflammation associated with gout.

Author List

Thomas MJ

Author

Michael J. Thomas PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Free Radicals
Humans
Neutrophils
Superoxides
Uric Acid