Faculty Collaboration Database

2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research. J Cardiovasc Transl Res 2015 Jun;8(4):269-77

Date

04/30/2015

Pubmed ID

25920443

Pubmed Central ID

PMC4475456

DOI

10.1007/s12265-015-9626-4

Scopus ID

2-s2.0-84931568348   18 Citations

Abstract

The rat has long been a key physiological model for cardiovascular research, most of the inbred strains having been previously selected for susceptibility or resistance to various cardiovascular diseases (CVD). These CVD rat models offer a physiologically relevant background on which candidates of human CVD can be tested in a more clinically translatable experimental setting. However, a diverse toolbox for genetically modifying the rat genome to test molecular mechanisms has only recently become available. Here, we provide a high-level description of several strategies for developing genetically modified rat models of CVD.

Author List

Flister MJ, Prokop JW, Lazar J, Shimoyama M, Dwinell M, Geurts A, International Committee on Standardized Genetic Nomenclature for Mice, Rat Genome and Nomenclature Committee

Authors

Melinda R. Dwinell PhD Professor in the Physiology department at Medical College of Wisconsin
Aron Geurts PhD Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Biomedical Research
Cardiovascular Diseases
Disease Models, Animal
Gene Expression Regulation
Genetic Markers
Genetic Predisposition to Disease
Genetic Techniques
Humans
Phenotype
Rats
Rats, Transgenic
Species Specificity