2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research. J Cardiovasc Transl Res 2015 Jun;8(4):269-77
Date
04/30/2015Pubmed ID
25920443Pubmed Central ID
PMC4475456DOI
10.1007/s12265-015-9626-4Scopus ID
2-s2.0-84931568348 (requires institutional sign-in at Scopus site) 22 CitationsAbstract
The rat has long been a key physiological model for cardiovascular research, most of the inbred strains having been previously selected for susceptibility or resistance to various cardiovascular diseases (CVD). These CVD rat models offer a physiologically relevant background on which candidates of human CVD can be tested in a more clinically translatable experimental setting. However, a diverse toolbox for genetically modifying the rat genome to test molecular mechanisms has only recently become available. Here, we provide a high-level description of several strategies for developing genetically modified rat models of CVD.
Author List
Flister MJ, Prokop JW, Lazar J, Shimoyama M, Dwinell M, Geurts A, International Committee on Standardized Genetic Nomenclature for Mice, Rat Genome and Nomenclature CommitteeAuthors
Melinda R. Dwinell PhD Professor in the Physiology department at Medical College of WisconsinAron Geurts PhD Professor in the Physiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsBiomedical Research
Cardiovascular Diseases
Disease Models, Animal
Gene Expression Regulation
Genetic Markers
Genetic Predisposition to Disease
Genetic Techniques
Humans
Phenotype
Rats
Rats, Transgenic
Species Specificity